Juvenile hyperbilirubinaemia is from the etiological aspect a heterogeneous group and affects in particular the adolescent population. The prevalence of juvenile hyperbilirubinaemia is relatively high, in the adolescent population 2 - 6%, with a predominance of boys. It comprises quite benign entities such as Gilbert’s syndrome, but under the symptomatology of isolated hyperbilirubinaemia in the initial stage also conditions with a progressive affection of the liver may develop such as Wilson’s disease, alpha 1 antitrypsin deficiency or low score chronic hepatitis. The task of the physician after diagnosis of juvenile hyperbilirubinaemia is to confirm the hepatic type of jaundice and during a longitudinal follow up make a more accurate diagnosis of isolated hyperbilirubinaemia in adolescents. During the time needed to make a more accurate diagnosis various lifestyle measures are necessary which may interfere with strenuous sports activities in adolescent patients, with their vocational training and its selection.

        Key words: juvenile hyperbilirubinaemia, Gilbert’s syndrome, adolescents