Fox-Fordyce disease is a relatively rare disease with typical clinical and histopathological picture. Its morphology and clinical course is shown on 5 clinical cases. Pathogenetically it is characterized by an inflammatory reaction due to an occlusion of apocrine gland ducts ending in hair follicle infundibulum by keratotic plug. Lesions are present in armpits, nipples and pubic area. Primary lesion are formed by non-confluent skin color papules, which can be lightly or deeple red in cases of accentuated inflammation. In 4 of 5 our female-patients the lesions were subjectively asymptomatic. In 4 patients histopathological examination was performed. The basic finding was hyperkeratotic plug in hair follicle infundibulum in combination with spongiosis or vesicle in the hair follicle wall under the plug. In 2 patients we observed also dilatation of an apocrine gland duct. For establishing histopathological diagnosis is, usually, necessary thorough serial cutting of a bioptic material, but microscopical picture is well reflecting the pathogenetical nature of the lesion and it is possible to consider it pathognomic.

        Key words: Fox-Fordyce disease - clinical picture - histopathological findings