By the administration of one therapeutic dose of both Ventolin syrup or two puffs of Ventolin inhaler, a serious alteration of the airway epithelium was produced. The ciliated cells were less altered compared to the secretory ones. After inhalation of Ventolin aerosol, the process of apical blebbing accompanied with the degeneration of some free kinocilia and with the impairment of the ciliary border was encountered. After administration of either Ventolin syrup or aerosol, the goblet cells were stimulated to discharge their mucus. The mechanism of secretion was accelerated. 30 min. after oral administration of Ventolin, signs of regeneration, resulting in secretory cells’ hyperplasia, were noticed. The peak of goblet cells stimulation was recorded 30 min. after inhalation of two puffs of Ventolin aerosol.

        Key words: salbutamol, tracheal epithelium, „Ventolin syrup“, Ventolin inhaler, electron microscopy