In 10 female patients with the diagnosis of secondary lymphoedema of the upper extremity after radical mastectomy with exenteration of the axilla, actinotherapy and chemotherapy the authors followed up for nine months the effect of systemic enzyme therapy on the state of lymphoedema and subjective sensations of the patients. The total period of treatment with Wobenzyme tablets was 12 weeks. During check-up examinations after 4-week intervals the authors assessed the volume of both upper extremities and from the values they calculated the relative volume of oedema. The investigation provided evidence of a favourable effect of systemic enzyme therapy on the state of lymphoedema of the upper extremity. During evaluation of subjective feelings the authors noted a decline of the functional dyscomfort and the feeling of heaviness in the oedematous extremity diminished. These changes were statistically signifi- cant. Systemic enzyme therapy with Wobenzyme in secondary lymphoedema of the upper extremity after mastectomy can be evaluated as favourable and effective.

        Key words: systemic enzyme therapy - lymphoedema after mastectomy - therapeutic effect.