Transformation growth factor (TGF-beta) is a cytokine, which takes part in many clinical conditions linked to
different chronic disease states. Its production is regulated by genes and polymorphism of TGF-beta gene individually
predetermines levels of its production. TGF-beta is produced by a number of normal, predominately haemopoietic
and tissue cells. Moreover, it controls cell proliferation and differentiation, and namely it stimulates fibrogenesis.
Profibrogenic efficacy plays a physiological role in wound healing and it is implicated in a spectrum of disease states,
such as diabetic nephropathy, chronic glomerulonepthritis, lung fibrosis, or postirradiation fibrosis. In kidney
transplant recipients, TGF-beta has been suggested to be involved in the chronic rejection pathogenesis by enhancing
cytokines, extracellular matrix, fibrogenesis, glomerulonephritis, chronic rejection, cyclosporin,