Amyloidosis is a summary of a group of disorders of protein metabolism characterized by infiltration of amorphous substance into the tissues. The diagnosis can rarely be made during life. It is usually manifested by defects of the renale, cardiovascular or peripheral nervous system Heterogenity of clinical and histological classification of amyloidosis and clinical course in comparison with autopsy findings are presented by two cases of general amyloidosis - secondary amyloidosis of the kidneys and primary amyloidosis with a fatal prognosis.

        Key words: amyloidosis, primary amyloidosis, secondary amyloidosis.