Background. Negative interference of bilirubin with assessment of creatinine concentration is generally known
from the biochemical aspect. The objective of the presented work was to find the bilirubin level and creatinine
concentration where this phenomenon has actually a clinical impact.
Methods and Results. In 200 samples selected at random the bilirubin and creatinine levels were examined by
the classical Jaffé method and a method where the effect of bilirubin is suppressed. After dividing the group into 8
sub-groups by bilirubin and creatinine concentrations it was revealed that the interference plays a statistically
significant role (p < 0.01) already at total bilirubin concentrations above 70 mmol . l
In abnormal creatinine levels
the interference is manifested only at bilirubin concentrations above 150 mmol . l
(p < 0.001). The degree of
interference in the whole group is directly proportional to the bilirubin level (r = 0.5497, p < 0.001).
Conclusions. At bilirubin levels above 70 to 150 mmol . l
its interference with assessment of the creatinine
concentration can be so significant that it must be taken into account when evaluating the patient’s renal function.
bilirubin interference, assessment of creatinine, Jaffé’s kinetic method.