Free radicals play an important role in the pathogenesis of inflammatory, degenerative and metabolic rheumatic diseases. Administration of Selzink Plus (PRO.MED.CS Praha a.s.), containing selenium, zinc, b-carotene and vitamins C and E, together with conventional antirheumatic therapy improves elimination of superoxide and its metabo- lites, thus increasing the patients’ prognosis. Long-term administration of this mixture seems to have even better results.

        Key words: rheumatic diseases, superoxide, free radicals, antioxidants.