Chronic lymphocytic leukemia represents the most frequent hematological malignancy in the western population.
Important role in its pathogenesis has the inhibition of apoptosis, disturbances in differentiation of B-lymphocytes,
slightly increased proliferation and induction of angiogenesis. Current treatment options (chemotherapy and immunotherapy)
can improve the quality of life and prolong disease-free survival, but the overall survival is not significantly
influenced. The only curative treatment alternative is the allogeneic hematopoietic stem cell transplantation.
However, this treatment is accompanied by the risk of peritransplantation mortality and its use is limited for younger
patients. Number of new compounds is clinically tested. New drugs can influence intracellular events such as induction
of apoptosis or inhibition of the transduction cascade. Review summarises treatment alternatives and presents an
algorithm for their clinical application.
chronic lymphocytic leukemia, chemotherapy, immunotherapy, stem cell transplantation.