Five to ten percent of oncological diseases exhibit monogenic mode of inheritance. They occure as a consequence
of the germline mutations of tumor supressor genes and of the genes engaged in reparative processes. Most common
monogenically determined oncological diseases are: AD form of breast and ovarian cancer, hereditary nonpolyposis
colorectal cancer (HNPCC, Lynch sy.) and familiar adenomatous polyposis (FAP). The aim of the genetic
investigation is to evaluate whether the index family deals with the hereditary form of tumor predisposition, than, if
possible, to perform DNA analysis in the family and to propose preventive screening program (methods) for the
probands in risk.
hereditary tumor predisposition, DNA analysis, predictive testing, prevention.