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  Česky / Czech version Čas. Lék. čes., 2007, 146, pp. 874–877.
 
Changes of Plasminogen Activator Inhibitor (PAI-1) During Estrogen Replacement Therapy 
Žižka Z., Fait T., 1Vrablík M. 

Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha 1III. interní klinika 1. LF UK a VFN, Praha
 


Summary:

       Background. The purpose of the present study was to determine changes of plasminogen activator inhibitor – 1 (PAI-1) as biochemical cardiovascular risk factor during the use of different administration methods in the early estrogen replacement therapy. Methods and Results. In a 12-week prospective, randomized, interventional, cross-over trial, oestradiol was administered orally in a dose of 2 mg daily or transdermally in a dose of 0.05 mg daily. Forty-five healthy postmenopausal women were included into the study within 12 weeks after the hysterectomy and ovariectomy (surgical castration). Forty-one women completed the study and their data were analyzed. The average age was of 49±6 years. PAI-1 was determined by bioimmunoassay (ChromolyzeTM PAI-1). The PAI-1 level decreased statistically significantly (p = 0.001) after the oral oestrogen therapy from 11.39±12.02 IU/l to 5.0±5.27 IU/l. Changes are also significant compared with non-significant changes after the transdermal therapy. Conclusions. The oral therapy reduced statistically significantly PAI-1 levels compared with the transdermal method of administration. This change is beneficial from the view of cardiovascular risk.

        Key words: Estrogen replacement therapy, cardiovascular risk, PAI-1.
       

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