Background. Evaluation of treatment results in children with hepatoblastoma – a retrospective study of clinical and
pathological data of surgically treated children.
Methods and Results. At the clinic of authors, 28 children were operated for hepatoblastoma during 1991 to 2002.
Average age of patients was 2.2 years. When tumors were classified according to PRETEX system, 3 children were
in the stadium I, 12 children in stadium II, 12 children in stadium III, and one child in the stadiumIV. At the diagnosis,
lung metastases were found in 3 children. Till 1996 the treatment was initiated by a primary operation, since 1996
by a preoperative chemotherapy. Chemotherapywas administered according to the SIOP protocols. Primary operation
was done in 13 children, 15 children were operated after the pre-operation chemotherapy. Liver resection included
right-sided lobectomy in 7 cases, extended right-sided lobectomy in 4 cases, left-sided lobectomy in 8 cases,
right-sided trisegmentectomy in 5 cases, left-sided trisegmentectomy in 3 cases. In our studied group the three years
of event free survival was achieved in 75%, overall survival in 86%. Four children died, two of them because of the
progression of the disease, two for the complication during the therapy.
Conclusions. Combination of the radical surgical resection with preoperative and postoperative chemotherapy
enables successful treatment of the childhood hepatoblastoma.
hepatoblastoma, liver resection in children, pre-operation chemotherapy, lung metastases, CUSA.