Endocrine pancreas producing insulin, glucagon, somatostatin and pancreatic polypeptide is under the influence of
different types of regulation; among them the regulatory role of enteropancreatic axis plays an important role. Incretin
effect of glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide 1 (GLP-1) is significantly
involved in the insulin secretion which is modulated by many other hormones. Diabetes mellitus, similarly to disturbances
of other hormones, can cause impaired regulation of insulin and other pancreatic hormones.
pancreatic hormones, insulin secretion, incretin hormones.