|CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ|
|Journals - Article|
|Česky / Czech version||Čes. slov. Farm. 51, 2002, č. 6, s. 310–312|
Therapy of Hyperhomocysteinemia by Vitamin B12
KRAJČOVIČOVÁ-KUDLÁČKOVÁ M., BLAŽÍČEK P.1, ŠEBEKOVÁ K., VALACHOVIČOVÁ M.
Ústav preventívnej a klinickej medicíny, Bratislava 1 Nemocnica Ministerstva obrany, Bratislava
Prevalence of mild hyperhomocysteinemia in vegetarians and vegans is a consequence of vitamin
B12 deficiency. Clinical study of homocysteine reduction by vitamin B12 consisted of subjective
healthy adults on alternative nutrition (n=9) with vitamin B12 deficiency and with mild hyperhomocysteinemia.
Vitamin B12 treatment was implemented by 5 intramuscular cyanocobalamin
injections of a total content of 2200 µg during two weeks. Homocysteine level was significantly
reduced (from 22 µmol/l to 11.7 µmol/l; individual reduction 29–55 %). Vitamin B12 concentration
in blood was significantly increased (from 152 pmol/l to 277 pmol/l; individual%of increase 63–150).
The results show a high effect of vitamin B12 treatment in homocysteine value reduction of subjects
on alternative nutrition.
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