In the second part of the review, functional polymorphisms of some other lipid-related genes are considered,
with a special emphasis on genetic variability of the fatty acid binding protein, lipoprotein lipase,
hepatic lipase, and PPARs. Gene polymorphisms can profoundly influence metabolic responses to various
dietary factors, e.g. effects of a special diet; on the other hand, dietary habits have modulatory effects
on the expression of specific genotypes. Atherosclerosis and cardiovascular disease develop as a result
of negative nutritional factors and individual genetic predisposition. A better comprehension of complex
gene-gene and gene-environment interactions involved in cardiovascular risk could contribute to new
preventive and therapeutic methods.
atherogenic dyslipidemias, gene polymorphisms, dietary factors, cardiovascular risk.