|CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ|
|Journals - Article|
|Česky / Czech version||Čes. slov. Farm. 51, 2002, No. 6, p. 305–309|
Preparation and Physico-Chemical Properties of Alkyl Esters of [(2-Hydroxy 3-diphenyl
—methylpiperazinyl)propoxy] Carbanilic Acids
OPATŘILOVÁ R., MOKRÝ P., CSÖLLEI J., BLEŠOVÁ M.
Ústav chemických léčiv, Farmaceutická fakulta VFU, Brno
The paper is devoted to the synthesis and study of some physico-chemical properties of a group of
substances – potential antagonists of beta-adrenergic receptors. The substances are derivatives of
aryloxyaminopropanol, where the basic part consists of diphenylmethylpiperazine and the aromatic
part is modified with alkyl esters (methyl to butyl) of carbamic acid in positions 2-, 3-, 4-. The
representation of the elements was confirmed by elemental analysis. The substances were characterized
by melting point, IR and UV spectra. Their solubility and surface acitivity were determined.
The purity of prepared substances was examined by means of TLC.
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