CzMA JEP Home page CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ
Journals - Article
CzMA JEP Home page News About Assocation Publishing Division Medical Journals Searching Supplements Catalogue
 
  Česky / Czech version Čas. Lék. čes., 141, 2002, No. 19, p. 605–609.
 
Some Less Known Risk Factors of Atherogenesis – Homocysteine, Lipoprotein (a) and C-reactive Protein 
Racek J., Racková M. 

Ústav klinické biochemie a laboratorní diagnostiky LF UK a FN, Plzeň
 


Summary:

       Atherosclerosis and its complications belong to the most frequent causes of morbidity and mortality in the developed countries. Far from all cases of early atherosclerosis can be explained by presence of „classical“ risk factors (hypertension, hypercholesterolemia, and namely by oxidised forms of lipoproteins of lowdensity, by smoking or due to not fully compensated diabetesmellitus). Our review brings information of another three serious risk factors – homocysteine, lipoprotein (a), and highly sensitive C-reactive protein. Metabolic relations among them are given as well as results of comparatively independent clinical studies and possibilities to influence these risk factors. Though they are comparatively independent, one feature connects them – they participate significantly on the development of endothelial dysfunction, which is supposed to be the initial stadium of atherogenesis.

        Key words: homocysteine, lipoprotein (a), C-reactive protein, atherosclerosis, risk factors, endothelial dysfunction.
       

Order this issue

  BACK TO CONTENTS  
 
 
| HOME PAGE | CODE PAGE | CZECH VERSION |
©  1998 - 2008 CZECH MEDICAL ASSOCIATION J. E. PURKYNĚ
Created by: NT Servis, s.r.o., hosted by P.E.S. consulting, s.r.o.
WEBMASTER