Background. Leptin is a new hormone influencing food intake, energy expenditure and body weight. This protein
is produced by adipocytes, exerts its effects on brain, endocrine pancreas and other organs by activating transmem-
brane receptors and is cleared from plasma mainly by the kidneys. The aim of our study was to compare plasma
concentrations of leptin in our nephrological out-patients and controls.
Methods and Results. We examined 36 diabetic patients with various stages of nephropathy, 12 males with
nephrotic syndrome due to membranous nephropathy, 15 dialysis patients and 11 controls. Leptin was assessed in
plasma by ELISA.
There was a significant difference between plasma levels of leptin in males and females (7.7 ± 11.4 vs 17.6 ± 17.3,
p < 0.001) and in dialysis and non-dialysis patients (19.6 ± 16.5 vs 10.7 ± 14.5, p < 0.05). There was also a difference
between dialysed and non-dialysed men (15.1 ± 16.2 vs 5.9 ± 9.2, p < 0.05). We found no difference between men
with and without nephrotic syndrome and between BMI or age. There was a positive corelationn of leptin with
diabetic and non-diabetic women. There was positive correlation of P-leptin with serum creatinine in non-dialysed
women (r = 0.68, p < 0.001) and a negative correlation with S-albumin in nephrotic men (r = -0.65, p < 0.05).
Conclusions. Women have higher plasma leptin concentrations than men and dialysis patients have higher
concentrations than non-dialysed patients. Apart from the positive correlation with S-creatinine in non-dialysed
women. There was positive correlation with S-albumin in nephrotic men there were no correlations with renal
function, BMI, age, S-cholesterol, S-triglycerides and S-albumin.
plasma leptin concentrations, renal disease.