Skeletal disorders represent ever-rising problem. Such diseases are of the highly heterogenous origin and for their
verification the laboratory diagnostic of metabolic skeletal changes cannot be omitted. Increasing knowledge on the
physiology and pathophysiology of the bone tissue metabolism and the use of new laboratory methods can improve
the diagnosis and treatment of such critical states. The article gives an overview of contemporary possibilities of the
laboratory diagnostic of metabolic skeletal changes. The significance, advantages, disadvantages and possible risks
in evaluation of individual osteomarkers are presented.
skeleton, bone tissue metabolism, laboratory diagnostic, osteomarkers.