Background. Prognosis of children with acute lymphoblastic leukaemia (ALL) – the most common cancer in
childhood, has improved remarkably over the last 40 years. The authors report the treatment outcome in children
with ALL cured according to ALL-BFM 90 Study protocol in the Czech Republic during the first half of nineties.
Methods and Results. Children aged 0–18 years were included into the study in 10 centers between 1990 to 1996.
Patients were classified into standard-risk (SR), medium-risk (MR) and high-risk (HR) group according to initial
leukaemic burden, early treatment response, and genotype of leukaemia. Duration of the chemotherapy was two
years. Treatment results were evaluated in 352 children. With a median follow-up of 7.3 years, event-free-survival
(EFS) was 71.3 % and overall survival 76.4 %. EFS was 80.3 %, 74 % and 28.2 % in SR, MR and HR group,
respectively. Relapse was diagnosed in 17.8 % of the patients.
Conclusions. The treatment outcome of children with ALL improved significantly (p=0.0045) compared to the
previous study ALL-BFM 83 (EFS 62 %). These results are comparable to those achieved by leading leukaemia
study groups in the world.
acute lymphoblastic leukaemia, chemotherapy, protocol ALL-BFM 90, relapse.