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  Česky / Czech version Čes. slov. Farm., 2004; 53, 192–196
 
Analysis of Tablets Containing the Antihistamine Loratadine: A Contribution to the Identification of Impurities 
ISSA N., MLYNÁROVÁ M. 

Štátny ústav pre kontrolu liečiv, Bratislava
 


Summary:

       Thin-layer chromatography on silica gel (Merck) was employed to examine potential impurities present in loratadine-containing tablets. A method usable for testing of impurities was elaborated, which suitably supplements the determination of loratadine content using the spectrophotometric method in the UV region. The method was validated for selected pharmaceuticals.

        Key words: laratadine – thin-layer chromatography (TLC) – impurities – validation
       

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