Cationic capillary isotachophoresis (ITP) with coductimetric detection has been used for separating
and determination of xanthinol in two commercial mass-produced preparations. The optimized ITP
electrolyte system consisted of 5 mM potassium picolinate + 5 mM picolinic acid (pH 5.21) as the
leading electrolyte and 10 mM formic acid as the terminating electrolyte. The driving and detection
currents were 50 mA (for 380 s) and 10 mA, respectively. The analysis took about 8 min. According
to the validation procedure based on the reference UV spectrophotometric method, the ITP method
gave practically the same results.
xanthinol – isotachophoresis – pharmaceutical analysis