Background. The aim of the work was to find out whether the controlled administration of a thrombolytic directly
into the arterial occlusion could prevent formation of the systemic lytic state, which may result in distant bleeding
Methods and Results. In patients subjected to pulsatile pharmacomechanical (94 patients) and local continual
thrombolysis (74 patients) changes in blood and plasma viscosity, coagulation tests, fibrinogene levels and some
other parameters were investigated.
Conclusions. Pulsatile pharmacomechanical thrombolysis, similarly to other forms of thrombolysis, is accompa-
nied with systemic lytic state and the risk of unwanted resorption of the hemostatic thrombosis. Urokinaze
administration brings about regress of systemic changes, which is similar to the use of either tested thrombolytic
administration. As treatment by the continual thrombolysistakes is approximately 40 times longer, the risk of systemic
lytic state and bleeding complication growths.
blood viscosity, urokinaze, local thrombolysis, ischaemic disease of the lower limbs.