Background. The aim of the work was to find out whether the controlled administration of a thrombolytic directly into the arterial occlusion could prevent formation of the systemic lytic state, which may result in distant bleeding complications. Methods and Results. In patients subjected to pulsatile pharmacomechanical (94 patients) and local continual thrombolysis (74 patients) changes in blood and plasma viscosity, coagulation tests, fibrinogene levels and some other parameters were investigated. Conclusions. Pulsatile pharmacomechanical thrombolysis, similarly to other forms of thrombolysis, is accompa- nied with systemic lytic state and the risk of unwanted resorption of the hemostatic thrombosis. Urokinaze administration brings about regress of systemic changes, which is similar to the use of either tested thrombolytic administration. As treatment by the continual thrombolysistakes is approximately 40 times longer, the risk of systemic lytic state and bleeding complication growths.

        Key words: blood viscosity, urokinaze, local thrombolysis, ischaemic disease of the lower limbs.