Background. Acute poisoning with the highly toxic organophosphorus agent, soman, is not treated satisfactorily
even by the most modern antidotes.
Methods and Results. In experiments on rats, the reactivating effect of a new asymmetric bispyridinium oxime BI-6
was compared with widely used oximes HI-6 and obidoxime by investigating the changes of soman-inhibited acetylcho-
linesterase activity in the diaphragm and various parts of the brain in rats up to three hours following soman challenge.
Our findings confirm that the new oxime BI-6 is a more effective reactivator of soman-inhibited acetylcholines-
terase than obidoxime but not as effective as the oxime HI-6 expecially in the peripheral compartment.
Conclusions. The new oxime BI-6 is not as effective as HI-6 which seems to have definite advantages over other
oximes in the treatment of soman poisoning.
soman, BI-6, HI-6, obidoxime, acetylcholinesterase, diaphragm, brain, rat.