Background. The worldwide elimination of iodine deficiency is at present one of the priorities of WHO. The
highest risk group with regard to sequelae of inadequate iodine supplies are even in case of a milder iodine deficiency,
human foetuses during the foetal and early infantile period (endemic cognitive disorder). An epidemiological survey
in three areas of the Czech Republic (Prague, Příbram, Ústí n. Labem) in 1993-95 in 5-day old infants and their
mothers provided evidence of a medium grade iodine deficiency in Prague and the Příbram area. The objective of
the epidemiological check-up survey of ioduria of neonates in 1997 (Prague, Příbram) is the evaluation of the success
of preventive provisions which were implemented for a period and educational activities, recommendations to take
100 mg iodine to all pregnant and lactating mothers, fortification of infant foods with iodine, increasing and improving
the standard of iodine in table salt (27 ± 7 mg l/kg salt as potassium iodate).
Methods and Results. In 1997 the ioduria of two groups of full-term neonates and their mothers was assessed on
the fifth day after delivery. Fifty neonates and their mothers were from Prague, 50 from Příbram. Ioduria was assessed
in morning urine samples by the method of Ing. Bílek (National list of laboratory items MZ, SLP type N-SPA-BANO,
code Joduria (photometry), key BIAAA, published in 1997). The results were statistically computed using Bartlett’s
chi-aquare and Kruskalov-Vallis’ H test and Student’s t-test. The median of ioduria in Prague neonates was 7.93 mg
l/100 ml and in Příbram neonates 7.83 mg l/100 ml urine. The median values of maternal ioduria were 5.90 mg l/100
ml in Prague and 7.23 mg l/100 ml urine in Příbram.
Conclusions. The median ioduria values of neonates from two areas (Prague and Příbram), previously (93-94) in
the zone of medium iodine deficiency, increased significantly during three years of intervention and in 1997 they
reached normal levels of ioduria for the given age group.
medium grade iodine deficiency, neonates, cognitive endemic disorder, intervention.