The paper summarizes the knowledge on the antihyperlipidemic effect of garlic, formulations
prepared from it, and the individual components, which were obtained prevalently in recent decade.
It presents varying opinions based on experimental results concerning the mechanisms by means
of which the effect takes place. In vitro experiments were carried out mainly on the cultures of rat
hepatocytes and an inhibitory effect on important enzymic activities taking place in the biosynthesis
of cholesterol and fatty acids was demonstrated. The most frequently employed in vivo models were
rabbits. The antiatherogenic effect was markedly manifested by a reduction of lipid plaques in the
arteries in hypercholesterolemic animals, decreased accumulation of cholesterol in vascular walls,
and other positive interventions.
Allium sativum – extracts – powders – isolates – antiatherogenic effect