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  Česky / Czech version Čas. Lék. čes., 138, 1999, No. 9, p. 268 - 271.
 
Autoantibodies in the Pathogenesis and Diagnosis of Insulin-dependent Diabetes Mellitus 
Prázný M., Škrha J. 

 


Summary:

       Insulin-dependent diabetes mellitus is considered an autoimmune disease. The immune response is targeted on autoantigens of B-cells of the islets of Langerhans. The most important autoantigens are glutamic acid decarboxylase, protein tyrosine phosphatase and insulin. Despite the fact that their role in the pathogenesis of insulin-dependent diabetes mellitus is not clear, they are used in diagnosis and can identify subjects at high risk for the development of the disease.

        Key words: insulin-dependent diabetes mellitus, autoimmune disease, autoantibodies, glutamate decarboxylase, tyrosine phosphatase.
       

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