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  Česky / Czech version Čes. a Slov. Farm., 51, 2002, No. 2, p. 73-77
 
Effects of Consupren, Carvedilol and BL-443 on Lactate Dehydrogenase Pattern in Tissues of Rats with Cyclosporine Nephropathy 
ŠALPLACHTA J., STRNADOVÁ V., CSOLLEI  

Ústav biochemie a bioýziky Fakulty veterinární hygieny a ekologie Veterinární farmaceutické univerzity, Brno Ústav humánní farmakologie a toxikologie Farmaceutické fakulty a Veterinární farmaceutické univerzity, BrnoÚstav chemických léčiv Farmaceutické fakulty a Veterinární a farmaceutické univerzity, Brno
 


Summary:

       L-Lactate dehydrogenase pattern in tissues was determined by polyacrylamide gel electrophoresis adjusted to be more sensitive to LDl and LD2. Three groups of rats (Wistar) were treated for 18 days with single oral daily doses of 45 mg consuprene/kg body weight to induce cyclosporine nephropathy. Two treated groups were further medicated either with carvedilol or BL-443 in single daily doses of 10 mg/kg b.w., unmedicated rats were given single i.p. daily doses of 1 ml saline. No significant difference in the LD(1-4) isoenzyme pattern in the liver between intact rats, rats with cyclosporine nephropathy, and rats with cyclosporine nephropathy medicated with carvedilol or BL-443 was found by F-test and t-test (p<0.05). However, a significant difference in the LD(1-4) isoenzyme pattern in the myocardium between rats with cyclosporine nephropathy and intact rats was found. The present study reports the preliminary results of the effects of consupren on the LD(1-4) pattern in the muscle, spleen, and lung, as well as the effects of carvedilol and BL-443 in the tissues under the conditions of experimental cyclosporine nephropathy. The tissues with an increased risk of affection can be identified by evaluation of LD patterns tkat may become an additional tool to microscopic examination of the sample.

        Key words: consupren - carvedilol - cyclosporine nephropathy - L-lactate dehydrogenase isoenzymes
       

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