Background. Evaluation of antibiotic consumption and the surveillance of bacterial pathogens resistance appears
to be an indispensable part of antibiotic policy. The aim of this study was to evaluate dynamics of antibiotics
consumption and resistance development in selected bacterial strains (Pseudomonas aueruginosa, Staphylococcus
aureus and Staphylococcus epidermidis) in the environment of Faculty Hospital.
Methods and Results. The analysis was focused on the development of antibiotic consumption and monitoring
of the development of bacterial resistance. Samples were taken in internal and surgical departments of General
Faculty Hospital in Prague in 1992, 1995, and 1999. The evaluation of antibiotic consumption was based on
Anatomical Therapeutic and Chemical classification system and the Defined Daily Doses (DDD). The consumption
in the follow up period almost doubled in surgical department while in internal medicine department was decreased
by almost one third. In both department, namely in the surgical one significant increase of bacterial resistance to
tested antibiotics was noted.
Conclusion. The important part of the local antibiotic policy is the monitoring of development of bacterial resistance
and consumption of antibiotics.
antibiotic consumption, bacterial resistance, antibiotic policy.