Chronic myeloid leukemia has got an outstanding position among the other oncology diseases, particularly
due to specific chromosomal abnormality called Philadelphia chromosome, its molecular consequence
BCR/ABL fusion gene and its biologic product BCR/ABL tyrosinekinase, which is responsible for
the leukemic transformation of the hematopoetic cells. We can see a real revolution in the treatment of
the chronic myeloid leukemia in the last few years. The authors pay attention to the developement of the
new drugs in the large historical consequences from the beginning in the 19th century (describing leukemia
first time) to the introduction of the new small specific molecules into the clinical practice.
chronic myeloid leukemia, tyrosinkinase, BCR/ABL, targeted therapy.