Multiple Sclerosis and Magnetic Resonance Imaging
Jinochová M., Seidl Z., Obenberger J., Krásenský J., 1Havrdová E., Viták T., Peterová V., Daneš J.
Radiodiagnostická klinika 1. LF UK a VFN, Praha 1Neurologická klinika 1. LF UK a VFN, Praha
Multiple sclerosis is a demyelinating process presently referred to autoimmune diseases. Its diagnostics is based on
clinical examination and paraclinical tests (magnetic resonance, examination of CSF and evoked potentials recording).
Magnetic resonance (MR) has the highest significance, both for the diagnostics and for the monitoring of the
course of disease and results of treatment. Results of magnetic resonance are not specific for the multiple sclerosis
and therefore for the reliable diagnosis the McDonadl’s criteria have to be fulfilled. It appears thatmagnetic resonance
is more sensitive to progression of disease than the clinical examination. Monitoring of the course of disease requires
new techniques ofMR imaging.Automatic, software assisted determination of plaque volumes in T2 and T1 weighted
images – so called „lesion load„, is checked during the patient’s treatment. Assessment of brain volume determines
progression of atrophy. The aim of all the new methods of MR imaging is to search for a reliable technique of the
disease monitoring and namely for the prediction of disease progression.
Multiple sclerosis, diagnostics, magnetic resonance imaging, volumetry.