Intravascular Brachytherapy in the Prevention of Vascular Restenosis
Dvořák J., Petera J., 1Fridrich J., 2Raupach J., 2Krajina A., 3Hůlek P., Melichar B., 4Malý J.
Klinika onkologie a radioterapie FN, Hradec Králové 1Oddělení kardiopulmonální a vaskulární diagnostiky FN, Hradec Králové 2Radiodiagnostická klinika FN, Hradec Králové3I. interní klinika FN, Hradec Králové 4II. interní klinika FN, Hradec Králové
Vascular restenoses currently represent amajor problemin the treatment of vascular stenoses. One of new approaches
in the prevention of restenoses is intravascular brachytherapy. Intravascular brachytherapy uses local irradiation of
the stenotic vessel segment by ionizing radiation with the aim of prevention of restenosis. This is a new rapidly
developing multidisciplinary approach based on collaboration of specialties of intervention radiology, intervention
cardiology, angiology, nephrology and radiation oncology. This review examines current options of intravascular
brachyterapy as well as results of clinical trials evaluating the efficacy of intravascular brachytherapy in the different
anatomical regions. Intravascular brachytherapy may substantially reduce the rate of restenoses. However, intravascular
brachytherapy should be currently used only in the setting of clinical trials. Optimal method of irradiation of
the stenotic segment of the vessel is still to be defined.
vascular restenosis, intravascular brachytherapy, percutaneous transluminal angioplasty, percutaneous
transluminal coronar angioplasty, dialysis arteriovenous shunt, transjugular intrahepatic portosystemic shunt.