Purpose: The purpose of our study was to evaluate an upcoming breast cancer diagnostic modality based on mea-surements of the red light absorption in the breast and response on pressure stimulus inducing circulating blood volume chan-ges. Patients and Method: Patients (n=100) with suspicious mammography finding underwent Dynamic Optical Breast Imaging (DOBI) followed by core-cut biopsy in Masaryk Memoriál Cancer Institute. Sensitivity and specificity were calculated to compare DOBI with mammography. Results: Both sensitivity and specificity (71% and 64% respectively) indicates that DOBI can be a promising minimum-stress method in malignant breast lesion detection.

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