The liver and the kidney jointly or in a complementary manner play an important role in maintaining homeostasis
of the internal environment, mainly regarding detoxification, excretion and regulation. Hepatorenal syndrome can
develop under pathological circumstances due to severe hepatic impairment, when the metabolism of both organs is
affected by various xenobiotics, when they are damaged by genetic defects as in renal polycystosis, glycogenoses,
alpha-1 antitrypsin deficiency or in hereditary amyloidosis. In primary hyperoxaluria or familiar thrombotic
microangiopathy renal impairment develops due to the metabolic defect in the liver. Both organs may be impaired
also in some hemolytic anemias, viral hepatitis, AIDS, leptospirosis, in circulatory failure, intoxications, and after
the bone marrow or solid organ transplantation. In the dialysis units, prevention of viral hepatitis and HIV infection
is of the basic importance; its principles are discussed in more detail.
liver, kidney, hepatorenal syndrome, detoxification, excretion, regulation, viral hepatitis.