 |
CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ |
| Journals - Article | |
 |
 |
| Česky / Czech version | Čes. a Slov. Farm., 50, 2001, No. 6, p. 303-307 |
|
HPLC Analysis of Non-Steroidal Antirheumatics in Biological Material
V. Fenamates SOCHOR J., KLIMEŠ J., SEDLÁČEK J., HNILOVÁ M. Katedra farmaceutické chemie a kontroly léčiv Farmaceutické fakulty Univerzity Karlovy, Hradec Králové, Katedra patologické fyziologie Lékařské fakulty Univerzity Karlovy, Hradec Králové |
|
Summary: The present paper surveys published HPLC methods estimating derivates of fenamic acid in
biological materials and an HPLC method for estimation of meclofenamic acid in the samples of
whole blood. Meclofenamic acid was isolated from the sample of the blood both liquid-liqud extraction
and solid-liquid extraction. For determination of meclofenamic acid in the blood was preferred
solid-liquid extraction. The adjust sample was analysed on reverse phase Separon SGX C-18 with
the mobile phase methanol – water (pH 2.3) and detected at 220 nm. The method was used in
a pharmacokinetic study of meclofenamic acid on rabbits.
|
|
|
Order this issue
|
|
| BACK TO CONTENTS | ||
| | HOME PAGE | CODE PAGE | CZECH VERSION | |
| © 1998 - 2008 CZECH MEDICAL ASSOCIATION J. E. PURKYNĚ |
| Created by: NT Servis, s.r.o., hosted by P.E.S. consulting, s.r.o. |
| WEBMASTER |