Chalcones and their heterocyclic analogues show various biological effects, e.g. anti-inflammatory,
antitumour, antibacterial, antituberculous, antiviral, antiprotozoal, gastroprotective, and others.
The present review discusses in greater detail the fungistatic and fungicide properties of these
compounds and presents also their chemical structures. The mechanism of antifungal effects of
chalcones and their analogues has not been investigated in greater detail. Due to the presence of
a reactive ketovinyl moiety in the molecule the compounds of this type are able to react with the
thiol groups of enzymes. It cannot be excluded that chalcones interfere with the normal function of
the membranes of fungi and moulds. Further investigation of chemical, physical, and biological
properties of chalcones and their analogues could lead to the elucidation of the mechanism of their
action and finding of effective fungicidal and fungistatic agents in this group of organic substances.
chalcones – heterocyclic analogues of chalcones – antifungal activity