The separation of antibodies is a process of great importance. The present paper deals with the
method of thiophilic adsorption chromatography (TAC) based on the thiophilic sorbents. Thiophilic
sorbents can interact with the immunoglobulins very selectively. Binding of immunoglobulins is
dependent on the high ionic strength of the medium. Sorbed immunoglobulins are released by the
ionic strength decay. TAC provides immunoglobulins from the plasma (or other sources) in one step.
Purity of immunoglobulins is comparable with results of the other methods. Benefits of TAC are
delicacy to immunoglobulins, simple handling and low costs of separation. By means of TAC it is
possible to eliminate immunoglobulins from biological materials. Thiophilic sorbents are currently
available but the possibilities of their exploitation are practically unknown.
antibodies – immunoglobulins – thiophilic adsorption –chromatography