CzMA JEP Home page CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ
Journals - Article
CzMA JEP Home page News About Assocation Publishing Division Medical Journals Searching Supplements Catalogue
 
  Česky / Czech version Čes. a Slov. Farm., 50, 2001, No. 4, p. 197-202
 
Analytical Evaluation of the Substance BL 443 Pivalate 
BEZÁKOVÁ Ž., STANKOVIČOVÁ M., CSÖLLEI J.  

Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava, Ústav chemických lieèiv Veterinárnej a farmaceutickej Univerzity, Brno
 


Summary:

       The paper presents the results of an analytical evaluation and a study of some physicochemical properties of a new potential drug of the prodrug type Œ the substance BL 443 pivalate with an assumed antidysrhythmic effect. The structure of the substance has been confirmed by elemental analysis, IR and UV spectroscopy. The following parameters were determined: melting point, solubility, dissociation constant, experimental partition coefficient in four different systems, and surface activity. The chromatographic behaviour of the drug on a thin layer (adsorption and partition chromatography) was also investigated. Acidimetric titration in non-aqueous medium and spectrophotometry in the ultraviolet region of the spectrum at the wavelength of the second absorption maximum of the drug was employed to determine the content of the drug in pure substance.

        Key words: prodrug - BL 443 pivalate: butylester of [(2-pivaloyloxy-3-isopropylamino)- -propoxy]phenylcarbamic acid - analytical profile - physicochemical properties
       

Order this issue

  BACK TO CONTENTS  
 
 
| HOME PAGE | CODE PAGE | CZECH VERSION |
©  1998 - 2008 CZECH MEDICAL ASSOCIATION J. E. PURKYNĚ
Created by: NT Servis, s.r.o., hosted by P.E.S. consulting, s.r.o.
WEBMASTER