Chronic hepatic porphyria is in some cases a paraneoplasia, in others part of the neoplastic disease. Sometimes it
is, on the other hand manifested during antineoplastic treatment. Its development may be associated with this therapy.
The presented case-history describes a female patient with breast cancer treated with antineoplastic agents, who
developed a sporadic form of late cutaneous porphyria with a classical clinical and laboratory picture.
The authors contemplate on the possible porphyrinogenic effect of antineoplastic agents, in particular cyclophos-
phamide and tamoxifen, which in the latter preparation was not described so far.
porphyria, porphyria cutanea tarda, PCT, porphyrogenicity, antineoplastic agents, 5-fluorouracil,