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  Česky / Czech version Čas. Lék. čes., 138, 1999, No. 17, p. 536 -538.
 
Porphyria Cutanea Tarda after Antineoplastic Drugs 
Malina L., Michalíková H., 1 Hussarová L. 

 


Summary:

       Chronic hepatic porphyria is in some cases a paraneoplasia, in others part of the neoplastic disease. Sometimes it is, on the other hand manifested during antineoplastic treatment. Its development may be associated with this therapy. The presented case-history describes a female patient with breast cancer treated with antineoplastic agents, who developed a sporadic form of late cutaneous porphyria with a classical clinical and laboratory picture. The authors contemplate on the possible porphyrinogenic effect of antineoplastic agents, in particular cyclophos- phamide and tamoxifen, which in the latter preparation was not described so far.

        Key words: porphyria, porphyria cutanea tarda, PCT, porphyrogenicity, antineoplastic agents, 5-fluorouracil, cyclophosphamide, tamoxifen.
       

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