The paper deals with analytical evaluation of newly prepared substances, derivatives of N-(4-alkoxy-
phenyl)-2-(2-oxo-azepan-1-yl)-acetamide. The substances are a homological series (methyl- to
hexyl-). The purity of the substances was verified by thin-layer adsorption chromatography, and the
principal physical characteristics – melting point and solubility – were determined. Experimental
determination of the partition coefficient, extraction of the substances between two liquids miscible
to a limited degree (n-octanol – water), determination of RM values by means of TLC partition
chromatography (glass plates DC-Fertigplatten® RP-8 F254S), determination of the capacity factor
by means of HPLC (column C18 Plaris®), and calculation by means of computer programmes were
employed to determine the lipophilicity of this series of substances. The antiradical activity of the
substances was evaluated by the method of extinguishing the stable radical 2,2-diphenyl-1-picrylhydrazyl.
Ascorbic acid, in which an antiradical effect had been demonstrated,was used for the sake
of comparison. The substances show a certain activity, but they do not reach the antioxidative effect
of ascorbic acid.
nootropic agents – partition coefficient – TLC – HPLC – DPPH