Background. The presence of autonomic neuropathy impairs the quality of life (orthostatic hypotension, impo-
tence, gastroparesis) or endangers the life of diabetics (sudden death, unawarness of hypoglycemia). The purpose
of the investigation was: 1. To assess the presence of the autonomic neuropathy of the cardiovascular and the
gastrointestinal systems and their mutual relationship. 2. To assess the relationship of found autonomic neuropathy
and the subjective symptoms which are typical to affected particular systems (cardiovascular, gastrointestinal,
genitourinary, sudomotor systems and the syndrom of unawareness of hypoglycemia).
Methods and Results. The group comprised of 25 type 1 diabetic patients (12 women and 13 men) mean age
40.5±11.6 (range 21Š57 years) with a mean duration of diabetes of 17.8±7.9 (range 4Š35 years), treated with
intensified insulin regimens. The cardiovascular autonomic neuropathy was automaticaly examined by the VariaPulse
TF 3 computer system. Scintigraphy was used to investigate the gastric emptying time of
Tc labelled rice. The
information about the subjective symptoms we collected from the questionnaire. For statistic analysis we used
Spearmen correlations and ANOVA. Results: 1. A statistically significant correlation was found between the
presence of the autonomic neuropathy of cardiovascular and gastrointestinal systems (r=0.634, p <0.0007). 2. We
didn™t find any relation among the cardiovascular autonomic neuropathy and the subjective symptoms of cardiovas-
cular system, respectively the gastrointestinal neuropathy (impair gastric emptying) and the subjective symptoms of
gastrointestinal system. We found a significant correlation between cardiovascular and gastrointestinal neuropathy
and erectil dysfunction (r=0.48, p<0.0078), (r=0.42, p<0.0388) and with the syndrom of hypoglycemia unawareness
(r=0.49, p<0.0057), (r=0.52, p<0.0075).
Conclusions. The evidence of the cardiovascular autonomic neuropathy is warning signal for the affected
autonomic neuropathy in other systems which are more complicated for diagnostic. The subjective symptoms don™t
correlate with the presence of the visceral neuropathy.
diabetes mellitus, cardiovascular autonomic neuropathy, gastroparesis, gastric emptying, visceral