|CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ|
|Journals - Article|
|Česky / Czech version||Čes. a slov. Farm. 49, 2000, No. 2, p. 82–87|
HPLC Analysis of Non-Steroidal Antirheumatics in Biological Material
IV. Acetic Acid Derivatives
SOCHOR J., KLIMEŠ J., SEDLÁČEK J. 1 , ČERMÁKOVÁ P.
The present paper surveys the published HPLC methods estimating derivatives of acetic acid in
biological materials and an HPLC method for estimation of indomethacine in the samples of whole
blood. The elaborated chromatographic conditions and process of isolation were applied also to the
analysis of tropesine and both drugs were determined simultaneously. The blood samples were
adjusted by liquid-liquid extraction and indomethacine (and tropesine) was analysed on the reverse
phase Separon SGX C-18 with the mobile phase methanol – water (pH 3.2) and detected at 254 nm.
The method was used in a pharmacokinetic study of indomethacine on rabbits.
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