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  Česky / Czech version Čes.slov.Farm.51,2002,č.4,s.168 –172
 
Pharmaceutical Importance of Allium sativum L. 3.Antibacterial Effect Against Helicobacter pylori 
SOVOVÁ M.,SOVA P.1 ,MRÁZOVÁ A.2  

Katedra farmaceutické botaniky a ekologie Farmaceutické fakulty Univerzity Karlovy,Hradec Králové 1 Výzkumný ústav Pliva-Lachema a.s.,Brno 2 Gočárova 687,Hradec Králové
 


Summary:

       The paper points out the risk factors which render possible the outbreak of infections due to the bacterium Helicobacter pylori manifesting itself as chronic gastritis.In a great extent it results in peptic and duodenal ulcers and can even lead to the development of adenocarcinoma and lymphoma of the stomach.The paper mentions the efficacy of previous and contemporary therapy.Possible use of garlic in the treatment of these infections is intensively investigated.At present mainly in vitro experiments showing promising results are performed.A minimum of experiments carried out with out-patients produced negative results.As they do not fulfil the parameters of clinical experiments, this question still remains open.

        Key words: antibacterial effect –in vitro –in vivo – garlic preparations –lipophilic thiosulphinates
       

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