Autologous stemcell transplantation has been successfully used in treatment of various hematologicalmalignancies
and solid tumors in children and adults. Published data have confirmed that bone marrow harvests and peripheral
blood stem cell collections frequently contain a significant number of tumor cells. Contaminating tumor cells can
contribute to the disease relapse in posttransplant period, so attempts are made to eliminate contaminating tumor
cells from autografts. In the case of allogenic transplantation, T-lymphocytes depletion from graft decreases the risk
of the graft versus host disease after transplantation. In this article we comment techniques available and method
used for elimination of tumor cells. Commentary is aimed on potential benefits and risks of every method.
ex vivo purging, bone marrow transplantation, minimal residual disease.