|CZECH MEDICAL ASSOCIATION J. Ev. PURKYNĚ|
|Journals - Article|
|Česky / Czech version||Čes. slov. Farm., 2005; 54, 207–210|
Ouabain: from an Arrow Poison to a New Steroidal Hormone
MUČAJI P., NAGY M., GRANČAI D.
Farmaceutická fakulta Univerzity Komenského v Bratislave, Katedra farmakognózie a botaniky, SR
For more than 200 years, cardiotonic glycosides have been used for the treatment of congestive heart failure.
Ouabain is a well-known arrow poison obtained from different Acokanthera or Strophanthus species. Much
information has now accumulated that this plant toxin and its congeners are mammalian steroid hormones
involved in the pathophysiology of cardiovascular diseases. There is an interesting fact that 50% patients with
essential hypertension have elevated levels of endogenous ouabain. A better knowledge of the interactions of
these compounds with the hormones of salt and water metabolism might help to improve the diagnosis and
therapy of hypertension.
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