The case report concerns a rare condition of combined substance induced mood disorder with depressive features in patient with hallucinogen persisting perception disorder. Suspected role of isotretinoin treatment of acne and SSRI antidepressive medication in outbreak of major depression and the suicidal behaviour of the patient is discussed.

        Key words: depression, suicidality, flashbacks, schizotypal disorder, isotretinoin, fluoxetin, SSRI, substance induced mood disorder.