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  Česky / Czech version Čas. Lék. čes., 142, 2003, No. 8, p. 474–478.
 
Bartter’s Syndrome – Hypokalemic Renal Tubular Syndrome 
Gazdíková K., Gazdík F. 

Klinika farmakoterapie Ústavu preventívnej a klinickej medicíny, Bratislava
 


Summary:

       Hypokalemia is associated with some renal diseases manifested by renal tubular acidosis (type I and II) or by renal tubular syndrome (Bartter’s, Gitelman’s and Liddle’s syndrome). Bartter’s syndrome, originally described by Batter and colleagues in 1962, is a set of closely related renal tubular disorders characterized by hypokalemia, hypochloremia, metabolic alkalosis and hyperreninemia with normal blood pressure. The underlying renal abnormality results in excessive urinary losses of sodium, chloride, potassium and calcium. Muscle weakness, polydipsia, polyuria and mental retardation can be also present. Affected children have poor growth rates and they appear malnourished. The article is focused on ethiopathogenesis, laboratory and clinical characteristics and on the treatment of Bartter’s syndrome.

        Key words: Bartter’s syndrome, hypocalemic renal tubular syndrome, hypokalemia, metabolic alkalosis.
       

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