Free light chains of
immunoglobulins in patient with renal insufficiency
Granátová J.1, Bolková M.1, Fantová L.2, Hornová L.2, Mašková Z.3, Horák J.4, Lánská V.5
1Oddělení klinické biochemie, Fakultní Thomayerova nemocnice, Praha 2Nefrologická ambulance, Centromed, a. s., Praha 3Oddělení klinické hematologie, Fakultní Thomayerova nemocnice, Praha 4Hematologická ambulance, Centromed, a. s., Praha 5Oddělení lékařské statistiky, IKEM, Praha |
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Summary:
The quantitative measurement of free light chains of immunoglobulins (FLC) in serum and their κ/λ ratio have been
integrated into the diagnostics of monoclonal gammopathy. The pathological κ/λ ratio in serum is a sign of dysregulation
of immunoglobulin synthesis and can be an early manifestation of B cell proliferative disorders. The FLC concentrations
in serum are dependent significantly on the kidney function, mainly on the glomerular filtration rate (GFR).
In our report the changes in concentration of FLCs and the κ/λ ratio in patients with reduced GFR are demonstrated in
dependence on the degree of GFR reduction.
Key words:
free light chains of immunoglobulins, κ/λ ratio, kidney impairment, monoclonal gammopathy, glomerular
filtration rate.
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