Color Vision Deficiency in
Alcoholics and its Relationship with the BDNF Polymorphism
Šerý O., Lochman J., Zvolský P.1, Hlinomazová Z.2, Novotný M.1
Laboratoř neurobiologie a molekulární psychiatrie, Laboratoře molekulární fyziologie, Ústav biochemie, Přírodovědecká fakulta MU, Brno, ředitel Ústavu biochemie doc. Ing. M. Mandl, CSc. Psychiatrická klinika 1. LF UK a VFN, Praha, přednosta prof. MUDr. J. Raboch, DrSc. 1 Oční klinika FN Brno, přednostka prof. MUDr. E. Vlková, CSc.2
Alcoholism induces the brain damage but it may also cause the color vision deficiency. In our association study
of genetic dispositions to the alcoholism in 167 alcoholics and 289 non-alcoholic controls, we studied a relationship
between candidate genes and alcoholism. In all subjects involved in this study many factors, e.g. color vision
deficiencies, were examined. Surprisingly, after the statistical analysis, we found that 47.9% of alcoholics have
problems with color vision deficiency and moreover that this color vision deficiency is in a relationship with the
polymorphism of BDNF (Brain-derived neurotrophic factor) gene. It is well known that BDNF plays a role in the
neurodevelopment of retina and in the protection of photoreceptors from apoptosis. Potential role of BDNF gene
in the color vision deficiency in alcoholics is discussed.
alcoholism, BDNF, retina, vision, color, apoptosis, GABA.