Gene polymorphysm of the principal pro- and anti-inflammatory cytokines, namely that of tumor
necrosis factor-α, interleukin (IL)-1ß, IL-6, IL-8 a IL-10, can influence the course of the physiological
tissue reaction to operation trauma. Recent clinical studies try to confirm that the patient’s phenotype
significantly determines both the intensity of post-surgical tissue response and the incidence of postsurgical
complications and therefore it represents an independent prognostic factor of the postsurgical
development. It appears that the impact of individual genetic variants can differ in the relation to the
seriousness of the posttraumatic SIRS and in the relation to the danger and prognosis of the sepsis. For
clinicians, such findings can be soon transformed into the estimation of perisurgical risks – including
genome profile of markers critical for the inflammatory, thrombotic, vascular and neurological response
to post-surgical stress.
tumor necrotising factor-α, gene polymorphysm, interleukin 6, postoperative sepsis.